Autologous stem cell transplant
Treatment Overview
What is a stem cell transplant?
Most stem cells are in your bone marrow. You also have some in your blood. Bone marrow stem cells turn into red blood cells, white blood cells, or platelets to help your body stay healthy. If your bone marrow is attacked by a disease such as leukemia, it can no longer make normal blood cells. In a stem cell transplant, healthy stem cells are placed in your body through an IV to help your bone marrow start to work right.
When the stem cells come from your own blood or bone marrow, it is called an autologous transplant.
When the stem cells come from another person, it is called an allogeneic transplant. The donor may be a relative or a complete stranger. The important thing is that the donor's blood is closely matched to yours. This is more likely when the donor is your brother or sister.
Stem cells can also be found in your bloodstream and in the blood inside a newborn's umbilical cord.
When is a stem cell transplant needed?
Stem cell transplants are used to treat diseases that damage or destroy the bone marrow. Such diseases include non-Hodgkin's lymphoma and Hodgkin's lymphoma, leukemia, multiple myeloma, and aplastic anemia.
Other uses for stem cells, such as the treatment of diabetes, sickle cell disease, and thalassemia, are being studied.
How do I know if I am a good candidate for a stem cell transplant?
Your doctor will consider your overall health and your age. People who are good candidates usually are younger than 70, do not have other diseases such as heart disease or diabetes, and have a normal kidney and liver. Your doctor will also consider how much your disease has grown and how aggressive your cancer is. People with aggressive cancer that has spread to many areas of the body are not usually thought to be good candidates. Your doctor may also consider whether you have cancer that has come back, such as relapsed non-Hodgkin's lymphoma.
How are stem cells collected?
It depends on where the stem cells come from. If they are taken from the bone marrow, a small amount of the liquid portion of the bone marrow is removed through a needle inserted into the bone. This is done many times to collect enough stem cells for the person getting the donated bone marrow. This is called a bone marrow aspiration.
If they are taken from blood, the growth factor G-CSF may be used to stimulate the growth of new stem cells so they spill over into the blood. G-CSF is a protein that is produced naturally in the body. G-CSF may be used so a transplant can be done as soon as possible and a chemotherapy dose does not have to be lower to allow stem cells to grow. The blood is removed from the vein in one arm and passed through a machine that separates the stem cells. The machine then returns the remaining blood through a needle in the person's other arm. This is called apheresis.
In adults, most autologous transplants use stem cells from blood. In a child, the decision whether to use cells from the bone marrow or the blood depends on the size of the child.
Why are chemotherapy and radiation therapy used before a transplant?
Before you have chemotherapy and radiation, you have blood taken and stored (banked) for later. Then you have chemotherapy and radiation to destroy your bone marrow. This gets rid of the cancer cells in your bone marrow. Later, when you get your stored blood cells back, those new cells will be able to take over the job of making new blood cells.
How are stem cells transplanted?
An IV is inserted in your neck or chest. The stem cells travel through the IV, into your blood, and to your bone marrow, where they will begin to produce new cells in 1 to 3 weeks. During this time:
- You will be in isolation and given antibiotics to prevent infection. Destroying your bone marrow cells with chemotherapy leaves your body unable to fight infection.
- Your blood will be tested often to check the levels of red blood cells, white blood cells, and platelets in your body.
- You may need to receive several transfusions of blood cells and platelets until your body begins to produce its own.
- You may need more antibiotics or other medicines if you get an infection.
What To Expect After Treatment
An autologous transplant usually causes fewer problems than an allogeneic transplant. Some people are able to receive part or even all of their treatment in an outpatient clinic. Even if you need to be in a hospital, you will not usually have to stay longer than 3 weeks.
Severe, often life-threatening infection can develop after a stem cell transplant. You will need to take antibiotics for several months to prevent infection.
Your immune system may take 1 to 2 years or longer to recover after a transplant. Bone marrow aspiration is used to check your bone marrow. You will need to have many immunizations updated. Check with your doctor to find out which immunizations you will need.
Why It Is Done
Autologous stem cell transplant is used:
- To treat diseases that damage the bone marrow, such as Hodgkin's lymphoma, non-Hodgkin's lymphoma, and multiple myeloma; to treat solid tumours, such as breast cancer or testicular cancer; and to treat tumours that develop from cells producing eggs or sperm (germ cell tumours), such as dysgerminomas and teratomas.
- Experimentally for gene therapy and the treatment of other diseases, such as diabetes.
How Well It Works
The success of a transplant depends on the type and stage of the disease and your age and general health.
The original disease may come back after the transplant. If relapse occurs after autologous transplant, chemotherapy or other treatments may be used.
Risks
Early complications usually occur within 5 to 10 days and include:
- Nausea and vomiting.
- Diarrhea.
- Mouth sores.
- Hair loss.
- Bleeding because of severe reduction in red blood cells, white blood cells, and platelets.
- Infection, such as pneumonia, shingles, or herpes simplex.
Other possible complications include:
- Depression.
- Infertility.
- Cataracts.
- Kidney, lung, and heart complications.
- Recurrent disease.
- Other types of cancer.
What To Think About
Transplants from your own marrow
Using your own stem cells in a transplant is safer than using someone else's, because your body will not reject your own stem cells. But it also means you are more likely to have a relapse.1 That is because your own marrow or blood may still contain leukemia cells. Cells from another donor may work better at attacking any leftover cancer cells still in your body.
Some studies show that treating your marrow or blood with certain drugs before it is put back into your body may increase your chances for getting better. These drugs are given to try to kill any leukemia cells that may still be around. Treating your marrow or blood in this way is called purging. Researchers are still studying whether purging is really helpful.1
Specialized hospitals
Not every hospital is able to perform transplants. You may have to travel to a hospital that has special equipment and specially trained doctors and nurses.
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| Author: | Douglas Dana Robin Parks, MS | Last Updated: August 29, 2006 |
| Medical Review: | Adam Husney, MD - Family Medicine Caroline S. Rhoads, MD - Internal Medicine Douglas A. Stewart, MD - Medical Oncology | |
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| Topic Contents | |
| Treatment Overview | |
| What To Expect After Treatment | |
| Why It Is Done | |
| How Well It Works | |
| Risks | |
| What To Think About | |
| References | |