Glycoprotein IIb/IIIa inhibitors for heart attack and unstable angina

Examples

Generic Name	Brand Name
abciximab	ReoPro
eptifibatide	Integrilin
tirofiban	Aggrastat

How It Works

These medicines prevent the formation of blood clots.

Why It Is Used

Glycoprotein IIb/IIIa inhibitors are typically used along with angioplasty, stenting, or atherectomy procedures. Glycoprotein IIb/IIIa inhibitors help prevent reclosure of the blood vessel (restenosis) after these procedures.¹ These medicines are often used along with ASA and heparin.

How Well It Works

After angioplasty

Glycoprotein IIb/IIIa inhibitors may reduce the chance of a heart attack when used after angioplasty with stenting and in people with unstable angina.² Although these medicines appear to be useful when given immediately after angioplasty and stenting, long-term use has not proven beneficial.

Abciximab is generally preferred over eptifibatide when angioplasty is performed. Abciximab has been shown to reduce the rate of future heart attack after angioplasty.³

Glycoprotein IIb/IIIa inhibitors may lower the risk of death in people who have angioplasty after a heart attack.⁴

Side Effects

Some side effects of these medicines may include:

• Increased bleeding (hemorrhage) in the brain, stomach, intestines, or other internal organs.
• Increased bruising.
• Stomach irritation.
• Allergic reaction.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

If you have unstable angina and are at medium to high risk of a heart attack, you may be a candidate for glycoprotein IIb/IIIa inhibitors.⁵

Glycoprotein IIb/IIIa inhibitors are only used in the hospital, such as before or after an angioplasty.

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Author:	Douglas Dana Robin Parks, MS	Last Updated: August 15, 2007
Medical Review:	Anne C. Poinier, MD - Internal Medicine Caroline S. Rhoads, MD - Internal Medicine Stephen Fort, MD, MRCP, FRCPC - Interventional Cardiology
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