Cyclosporine for ulcerative colitis

Examples

Generic Name	Brand Name
cyclosporine	Neoral

How It Works

Cyclosporine is a medicine that weakens or suppresses the immune system, which may help decrease inflammation in the digestive tract.

Why It Is Used

Cyclosporine is used for inflammatory bowel disease (IBD) that has not responded to other medicines.

How Well It Works

Medicines that suppress the immune system have been effective against IBD. Cyclosporine usually is used for ulcerative colitis that does not respond to other medicines. Cyclosporine tends to work more quickly than other immunosuppressive medicines, such as azathioprine or 6-mercaptopurine, during an acute attack of IBD.¹

This medicine may be used in severe cases when people do not get better on corticosteroids, but in one study 18% to 43% of people did not improve on cyclosporine.²

Cyclosporine has been shown to reduce the need for surgery in acute attacks of IBD. This allows people to try other medicines to suppress IBD symptoms.

Cyclosporine also is used in treating abnormal connections (fistulas) of the intestines in Crohn's disease. In rare cases, cyclosporine may be used in people with Crohn's disease that does not improve with other medicines.

Side Effects

Side effects of cyclosporine include:

• Kidney problems (temporary decrease in kidney function).
• Increased risk of infections.
• Blood sugar problems (diabetes).
• Increased cholesterol levels.
• Sleep problems.
• Headache, mild tremor, or tingling of the fingers and feet.
• High blood pressure.
• Increased hair growth.

Rare side effects include:

• Depression.
• Allergic reaction.
• Kidney failure.

When taking cyclosporine, blood pressure and kidney function should be checked regularly.

Talk to your doctor or pharmacist about drinking grapefruit juice while you are taking cyclosporine. Grapefruit juice can increase the level of this medicine in your blood. Having too much medicine in your blood raises your chances of having serious side effects. Regular blood tests can be used to monitor the level of cyclosporine.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Cyclosporine is most effective when given in a vein (IV), so it usually is used in people with severe symptoms who need hospitalization. Oral cyclosporine may not be as effective as the IV medicine in treating IBD or in maintaining remission. However, the oral medicine often is used after remission from IV medicine.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Author:	Douglas Dana Monica Rhodes	Last Updated: February 23, 2007
Medical Review:	Adam Husney, MD - Family Medicine Kathleen Romito, MD - Family Medicine Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
© 1995-2008 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.