Mitoxantrone

Examples

Generic Name
mitoxantrone

Mitoxantrone is given as an intravenous (IV) injection.

How It Works

Mitoxantrone belongs to a group of medications that interfere with the growth of the cancer cells (antineoplastics). It is used to treat some kinds of cancer.

Why It Is Used

Mitoxantrone is used to treat acute myelogenous leukemia (AML) and non-Hodgkin's lymphoma (NHL). It may also be used to treat other kinds of cancer. Mitoxantrone is also used to treat multiple sclerosis.

How Well It Works

Mitoxantrone is an effective treatment for non-Hodgkin's lymphoma and acute myelogenous leukemia. It also reduces the frequency of relapses of multiple sclerosis.

Side Effects

Side effects of mitoxantrone are common and can include:

• Nausea or vomiting.
• Hair loss.
• Damage to the muscle of the heart. This can be serious.
• Increased risk of infections, especially urinary tract infections.
• Changes in a woman's menstrual cycle.
• Mouth sores (stomatitis).
• Diarrhea or constipation.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Mitoxantrone should be administered only under the supervision of a medical oncologist, hematologist, or neurologist.

Mitoxantrone may cause serious, even fatal, heart damage in some people. Frequent tests are needed to monitor heart function while taking this medication.

Mitoxantrone can affect your ability to have children. You may not be able to become pregnant or father a child after taking mitoxantrone. Discuss fertility with your doctor before starting treatment with this drug.

Mitoxantrone can cause birth defects. Do not use this medication if you are pregnant or wish to become pregnant or father a child while you are taking it.

Women who take this medication may experience menopausal symptoms, including hot flashes and vaginal dryness.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Author:	Douglas Dana Kathe Gallagher, MSW	Last Updated: April 9, 2007
Medical Review:	Caroline S. Rhoads, MD - Internal Medicine Joseph O'Donnell, MD - Hematology/Oncology Donald Sproule, MD, CM, CCFP, FCFP - Family Medicine
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