Fludarabine

Examples

Generic Name	Brand Name
fludarabine	Fludara

Fludarabine is available as an oral and intravenous (IV) medication.

How It Works

Fludarabine is an antimetabolite medication. It causes cell death by interfering with the way genetic material (DNA) in the cell multiplies.

Why It Is Used

Fludarabine is used in combination with other medications to treat chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).

How Well It Works

Fludarabine is an effective treatment for chronic lymphocytic leukemia (CLL) that has not responded to other types of chemotherapy, such as chlorambucil or cyclophosphamide. Studies are ongoing to determine the safety and effectiveness of fludarabine in people who have not received other types of chemotherapy or who are responding to other types of chemotherapy.

Side Effects

Side effects are common with fludarabine and can include:

• Severe rapid destruction of red blood cells (hemolytic anemia).
• Decreased platelet counts (thrombocytopenia), which may lead to bleeding in the digestive tract, causing tarry stools.
• Joint pain.
• Blood in urine or stools.
• Blurred vision.
• Chest pain or discomfort.
• Diarrhea.
• Cough, wheezing, hoarseness, or shortness of breath.
• Confusion.
• Fever or chills.
• General feeling of discomfort or illness (malaise).
• Mouth sores (stomatitis),
• Nausea or vomiting.
• Painful, burning, or difficult urination.
• Rapid or irregular heartbeat (arrhythmia).
• Hair loss (uncommon side effect).

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Fludarabine should be administered only under the supervision of a medical oncologist or hematologist.

You may not be able to become pregnant or father a child after taking this medication. Discuss fertility with your doctor before starting treatment.

Fludarabine can cause birth defects. Do not use this medication if you are pregnant or wish to become pregnant or father a child while you are taking it.

Fludarabine can interact with many other medications. Be sure that your health professional has a complete list of all prescription and non-prescription medications you are taking.

Do not drink alcoholic beverages or take medications containing ASA while being treated with fludarabine, because these can cause bleeding from your stomach.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Author:	Douglas Dana Robin Parks, MS	Last Updated: August 29, 2006
Medical Review:	Adam Husney, MD - Family Medicine Caroline S. Rhoads, MD - Internal Medicine Douglas A. Stewart, MD - Medical Oncology
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