Etanercept for juvenile idiopathic arthritis

Examples

Generic Name	Brand Name
etanercept	Enbrel

How It Works

Etanercept is a genetically engineered protein that slows or stops idiopathic arthritis inflammation and joint damage. It has been studied and approved for use in treatment of children ages 4 to 17 who have juvenile idiopathic arthritis (JIA).

idiopathic arthritis inflammation is caused in part by a substance called tumour necrosis factor (TNF) in the joint area; etanercept deactivates TNF.¹

Why It Is Used

Etanercept is used to treat moderate to severe idiopathic arthritis symptoms and to prevent joint damage, particularly in people who have had side effects or poor results from methotrexate treatment.

When first approved for use, etanercept treatment was used only after methotrexate treatment had been unsuccessful. However, recent research suggests that etanercept works more quickly and more effectively prevents joint damage than methotrexate. (Long-term studies have yet to confirm whether etanercept prevents joint damage over a number of years.) As a result, Health Canada's Therapeutic Products Directorate (TPD) has approved etanercept for treating early stages of the disease. It may be a treatment option for a child who has not responded to non-steroidal anti-inflammatory drugs (NSAIDs).

Etanercept has shown positive preliminary results as a treatment for JIA-related inflammatory eye disease when combined with methotrexate and corticosteroid eyedrops.²

How Well It Works

Etanercept:

• Improves joint pain and swelling as soon as 2 weeks from the beginning of treatment.
• In a recent preliminary study, etanercept improved symptoms in 80% of children with polyarticular JIA (polyarthritis). This improvement was maintained for 2 years after treatment began.³ In another study of children with severe, long-standing polyarticular JIA who have not been helped by methotrexate, etanercept provided symptom improvement that was sustained for at least 2 years (the period of the study).⁴
• Has shown promising results in safely improving vision in a small sample of children with JIA-related inflammatory eye disease (uveitis).²
• May not be an effective treatment for a child with systemic JIA.⁵
• Is not recommended for treating pauciarticular JIA.

Side Effects

Side effects of etanercept are usually minimal, including:⁵

• Irritation and redness at the injection site.
• Runny nose and cough (upper respiratory infection).
• Headache.
• Gastrointestinal symptoms.
• Rash.

Etanercept suppresses the immune system, making it difficult for the body to fight infection. Therefore, etanercept cannot be given to a person with an active viral or bacterial infection, nor within 3 months of a live-virus vaccine. If your child develops a sore throat, cough, fever, or skin or bladder infection, contact your child's health professional immediately.

Etanercept can reactivate tuberculosis (TB) in people who have been previously infected with TB. Before starting etanercept treatment, your child should be screened for tuberculosis.⁶ Screening is usually done with a tuberculin skin test and possibly a chest X-ray.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Etanercept treatment is very expensive. Your provincial health plan may cover all or part of the cost, but coverage varies from province to province.

Further study is needed to determine whether etanercept has any dangerous long-term effects.

Etanercept is not used to treat people with lupus or multiple sclerosis, based on rare reports of etanercept worsening these diseases.

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Author:	Douglas Dana Shannon Erstad, MBA/MPH	Last Updated: August 30, 2006
Medical Review:	Adam Husney, MD - Family Medicine Michael J. Sexton, MD - Pediatrics Ross E. Petty, MD, PhD, FRCPC - Pediatric Rheumatology
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