Histamine H2 acid reducers for peptic ulcer disease

Examples

Generic Name	Brand Name
cimetidine	Tagamet, Tagamet HB
famotidine	Pepcid, Pepcid AC
nizatidine	Axid
ranitidine hydrochloride	Zantac, Zantac 75

Histamine H2 acid reducers (commonly called H2 blockers) are available in non-prescription and prescription forms.

H2 blockers are usually taken by mouth, although some can also be given as an injection. Two doses (morning and evening) are generally recommended to control both daytime and nighttime symptoms. Doctors sometimes recommend a single dose, taken at bedtime.

How It Works

H2 blockers decrease the production of stomach acid, which may reduce irritation to the stomach lining and help an ulcer heal.

Why It Is Used

H2 blockers often are used to treat a peptic ulcer or symptoms of indigestion (dyspepsia). Serious complications from these drugs are uncommon.

How Well It Works

H2 blockers are often effective treatments for indigestion or heartburn. All four appear to work equally well.

H2 blockers are often able to control the symptoms of an ulcer. But they cannot cure an ulcer that is caused by an infection with H. pylori bacteria. H2 blockers are sometimes used in combination with antibiotics to treat H. pylori infections.

Side Effects

Few side effects happen with short-term use of H2 blockers. Side effects may include:

• A headache.
• Dizziness.
• Diarrhea.
• Constipation.
• Nausea.
• Vomiting.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Antacids and H2 blockers should not be taken within 2 hours of each other because the antacid will cause the H2 blockers to take effect more slowly.

Some people find that taking a single bedtime dose of an H2 blocker effectively relieves their symptoms. This schedule is also very convenient.

Prescription-strength cimetidine and ranitidine are available in a generic form. This may be a cost-effective alternative for some people. Ask your doctor whether using a generic form of one of these medicines is right for you.

H2 blockers are generally thought to be safe for pregnant women to use. But discuss this with your doctor if you want to use them during pregnancy.

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Author:	Ralph Poore Monica Rhodes	Last Updated: February 28, 2008
Medical Review:	Kathleen Romito, MD - Family Medicine Andrew H. Soll, MD - Gastroenterology Andrew Swan, MD, CCFP, FCFP - Family Medicine
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