Asthma medications for children age 5 and younger

It can be difficult to decide how to use asthma medication in children age 5 and younger. Children in this age group who have moderate persistent to severe persistent asthma need to be under the care of a specialist. Children younger than 5 who have mild persistent asthma sometimes may need an asthma specialist.

Nebulizers are often used for babies and children who are too young to properly use inhalers. Nebulizers for small children have a face mask that ensures that they inhale the medication. Using a metered-dose inhaler with a spacerClick here to see an illustration. and face mask for babies is just as effective as using a nebulizer.

Studies that compare medications in this age range aren't available. However, the U.S. National Asthma Education and Prevention Program (NAEPP) has recommended the following approach for using medication in children age 5 and younger.1

Asthma medicine recommendations for children
Asthma severity Medicines required to maintain long-term control

Severe persistent

Preferred:

  • High-dose inhaled corticosteroids, AND
  • Long-acting inhaled beta2-agonists, AND IF NEEDED
  • Corticosteroid tablets or syrup long-term (2 mg/kg/day, generally not to exceed 60 mg/day). Make repeated attempts to reduce tablets or syrup, and maintain control with high-dose inhaled corticosteroids. Treatment by a specialist is recommended if your child is using oral corticosteroids long-term.

Moderate persistent

Preferred:

  • Low-dose inhaled corticosteroids and long-acting inhaled beta2-agonists OR
  • Medium-dose inhaled corticosteroids

Alternative:

  • Low-dose inhaled corticosteroids and either leukotriene pathway modifier (also called leukotriene receptor antagonist) or theophylline (a methylxanthine)

If needed (particularly in children with recurring severe attacks):

  • Preferred:
    Medium-dose inhaled corticosteroids and long-acting beta2-agonists
  • Alternative:
    Medium-dose inhaled corticosteroids and either leukotriene pathway modifier or theophylline

Mild persistent

Preferred:

  • Low-dose inhaled corticosteroid

Alternative:

  • Leukotriene pathway modifier

Mild intermittent

No daily medication needed

Quick relief:   All patients

  • Bronchodilator as needed for symptoms. Intensity of treatment will depend on severity of attack.
    • Preferred: Short-acting beta2-agonists
  • With viral respiratory infection:
    • Bronchodilator every 4 to 6 hours up to 24 hours (longer with physician consult); in general, repeat no more than once every 6 weeks.
    • Consider systemic corticosteroid if attack is severe or if child has a history of previous severe attacks.
  • Use of short-acting beta2-agonists more than 2 times a week in intermittent asthma (daily, or increasing use in persistent asthma) may indicate the need to start (increase) long-term control therapy.

Leukotriene pathway modifiers are available in oral formulations (swallowed rather than inhaled) that may be more convenient for young children.

Infants and young children should receive long-term treatment if they have had more than three wheezing episodes in the past year lasting more than 1 day and they have risk factors for asthma such as allergic rhinitis or a parent with a history of asthma.1

If your child has severe asthma attacks, he or she may need to take corticosteroids by mouth. Corticosteroids by mouth also may be necessary at the beginning of a viral respiratory infection.



Author: Douglas Dana
Maria G. Essig, MS, ELS
Last Updated: June 13, 2007
Medical Review: Anne C. Poinier, MD - Internal Medicine
Michael J. Sexton, MD - Pediatrics
Robert L. Cowie, MB, FCP(SA), MD, MSc, MFOM - Pulmonology
Harold S. Nelson, MD - Allergy and Immunology

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