Heart failure is the most serious complication and the
leading cause of death from
mitral valve stenosis.
In mitral valve stenosis, the valve opening narrows, and the heart
initially compensates by pumping harder. Eventually, however, pressure builds
in your left atrium as more and more force is needed to push blood across your
narrowing mitral valve. This eventually stretches the atrium's walls, weakens
the heart, and leads to heart failure.
A narrowed mitral valve may also not close properly and the valve may
begin to leak, causing
mitral valve regurgitation. The stenosis also causes
pressure to build up in the lungs (pulmonary hypertension), which can lead to
the pulmonic valve leaking (pulmonic regurgitation). When pulmonary
hypertension occurs, it may lead to right-sided heart failure.
As fluid gathers within the heart and lungs, the heart must exert
even greater force to pump blood to the body—further weakening the heart and
causing even more fluid buildup—thereby creating a vicious cycle. Eventually
the heart loses its ability to pump, resulting in heart failure and often
death.