Medications that increase the chance for a heat-related illness

Many medications change your body's ability to stay cool.

  • Medications that lower the amount of blood pumped by the heart (cardiac output) so blood flow to the skin is less include:
    • Antispasmodics, such as Levsin.
    • Diuretics, such as Dyazide or Lasix (Furosemide).
    • Beta-blockers, such as Inderal.
    • Calcium channel blockers, such as Cardizem.
    • Anti-Parkinson medications, such as Sinemet.
  • Medications that increase how much heat your body makes include:
    • Thyroid hormone, such as Synthroid, if you take too much.
    • Salicylates (ASA products).
  • Medications that change your sense of thirst in hot environments include:
    • Neuroleptics, such as Haldol.
    • Sedatives, such as Nembutal or Excedrin PM.
  • Medications that lower your body's ability to keep the temperature in a normal range (thermoregulation) include:
    • Antihistamines, such as Benadryl and other non-prescription cold remedies.
    • Anticholinergics, such as Buscopan.
    • Phenothiazines, such as Chlorpromazine.
    • Benztropine mesylate, such as Cogentin.
    • Tricyclic antidepressants, such as Elavil or Sinequan.
    • Monoamine oxidase inhibitors (MAOIs), such as Nardil.

Alcohol and illegal drugs, such as methamphetamines, amphetamines, cocaine, heroin, PCP (phencyclidine hydrochloride), and LSD (lysergic acid diethylamide), also affect your ability to sense dehydration or heat-related symptoms. These substances also reduce your judgment about whether treatment is needed for a heat-related illness.



Author: Jan Nissl, RN, BSLast Updated: January 31, 2007
Medical Review: Martin Gabica, MD - Family Medicine
Anne C. Poinier, MD - Internal Medicine
H. Michael O'Connor, MD - Emergency Medicine

© 1995-2008 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Click here to learn about Healthwise
Click here to learn about Healthwise