Toxic megacolon occurs when the colon swells to many times its normal
size. It is most commonly caused by severe inflammation and ulceration from
ulcerative colitis or
Crohn's disease, which weaken muscles in the
colon.
Over time, holes (perforations) may develop in the colon, and stool
may spill into the abdominal cavity, causing a serious infection.
Toxic megacolon is an emergency situation requiring immediate medical
and surgical treatment. If it is not treated, death may occur.