Medicines that can cause headache

Sometimes prescription and non-prescription medicines can cause headaches, especially if you use them regularly. Medications that may cause headaches include:

  • Birth control pills (oral contraceptives).
  • Caffeine (or caffeine withdrawal).
  • Cold medicines, such as antihistamines and decongestants.
  • Ergotamine (Cafergot) therapy.
  • Heart and blood pressure medicines (vasodilators).
  • Hormone therapy.
  • Overuse of fat-soluble vitamins, such as vitamin A and vitamin D.

Often, if you stop taking the medicine or take a smaller dose, your headache will go away. If you suspect your headache is caused by a prescription medicine, talk with your health professional about your side effects. Do not stop taking the medicine until you have spoken with your health professional.

Consider whether non-prescription medicines, alcohol, or caffeine are causing your headache. Try limiting the use of these to see if your headache goes away. Use caution with alternative therapies; some alternative therapies may cause headaches. Talk to your health professional about any alternative therapies you are using.

Rebound headache is a type of chronic headache that can result from overuse of pain medicines. This is often a problem for people who have frequent, severe headaches. A pain medicine may work for a limited period of time, but as the effect wears off, the headache returns, often worse than it was before. The person then takes more pain medicine, the effects again wear off, and the headache returns (rebound headache). Medicines that can cause rebound headaches include:

  • Non-prescription medicines, such as acetaminophen, ASA, or non-steroidal anti-inflammatory drugs (NSAIDs).
  • Prescription pain medicines, such as codeine or hydrocodone.

If you think your headache may be caused by a non-prescription medicine and you feel you need to continue taking the medicine, talk with your health professional.



Author: Sydney Youngerman-Cole, RN, BSN, RNCLast Updated: September 15, 2006
Medical Review: William M. Green, MD - Emergency Medicine
H. Michael O'Connor, MD - Emergency Medicine

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