Medications that can cause weakness or fatigue

Many prescription and nonprescription medications can cause generalized weakness and fatigue. The degree of weakness and fatigue caused by a certain medication will vary from person to person.

Medications that may cause weakness or fatigue include:

  • Anti-anxiety medications, such as Librium, Valium, or Xanax.
  • Antihistamines, such as Benadryl or Chlor-Tripolon.
  • High blood pressure medications (antihypertensives), such as Aldomet, Inderal, Lopressor, verapamil, Catapres, or reserpine.
  • Diuretics, such as hydrochlorothiazide, Dyazide, Lasix, or spironolactone.
  • Pain medication, such as codeine, or Darvon.
  • Steroids, such as prednisone, methylprednisolone, or dexamethasone.
  • Tricyclic antidepressants, such as Elavil or Tofranil.

If you think a prescription or nonprescription medication may be causing your fatigue or weakness, call your health professional.



Author: Jan Nissl, RN, BSLast Updated: April 17, 2007
Medical Review: William M. Green, MD - Emergency Medicine
Colin Chalk, MD, CM, FRCPC - Neurology

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