Non-steroidal anti-inflammatory drugs (NSAIDs)
Non-steroidal anti-inflammatory drugs (NSAIDs) reduce fever and inflammation and relieve pain. Examples of NSAIDs include ASA, ibuprofen, naproxen, and ketoprofen.
Be sure to follow the non-prescription medicine precautions. Always take these medicines exactly as prescribed or according to the label.
Ibuprofen (such as Motrin or Advil)
- Adults: The initial dose is 400 mg. Follow-up doses are 200 mg to 400 mg every 4 hours as needed, up to a maximum of 4 doses in a 24-hour period.
- Children: Ibuprofen should be used in children who are 3 months to 2 years old only if your health professional has instructed you on the proper dose and timing of doses. This non-prescription medication may be used in children who are 2 years and older; dosages are based on the child's weight. Give follow-up doses every 6 hours as needed, up to a maximum of 4 doses in a 24-hour period.
Ibuprofen dose for your child's weight Child's weight in kilograms (kg)
Child's weight in pounds (lb)
Child's age
Dose
Less than 11 kg
Less than 24 lb
Younger than 2 yrs
Ask a doctor
11–16 kg
24–35 lb
2–3 yrs
100 mg
17–21 kg
36–47 lb
4–5 yrs
150 mg
22–27 kg
48–59 lb
6–8 yrs
200 mg
28–32 kg
60–71 lb
9–10 yrs
250 mg
33–43 kg
72–95 lb
11 yrs
300 mg
44 kg and above
96 lb and above
12 yrs and older
Adult dose
Side effects
The most common side effects of NSAIDs are stomach upset, heartburn, and nausea. To help prevent these side effects, take NSAIDs with food and a glass of water.
- NSAIDs can cause a severe allergic reaction. Symptoms may include hives, swelling of the face, wheezing, and shock. If you have any of these symptoms, call911or other emergency services immediately.
- For safety, read the label carefully and do not take more than prescribed. Taking a larger dose or taking the medicine longer than recommended can increase your risk of dangerous side effects.
- Do not use a non-prescription NSAID for longer than 10 days without talking to your doctor.
Reasons to stop taking NSAIDs
NSAIDs may delay healing. If you develop any of the following signs of infection, stop taking the medication:
- An increase in pain
- Skin that is hot to the touch around the injury or wound
- Redness or red streaks extending from the injury or wound
- Pus that continues to form in the wound
- Fever with no other cause
- Swollen glands above the injury or wound
NSAID risks
- NSAIDs have the potential to increase your risk of heart attack, stroke, skin reactions, and serious stomach and intestinal bleeding. These risks are greater if you take NSAIDs at higher doses or for longer periods than recommended.
- ASA, unlike other NSAIDs, has been shown to reduce the risk of heart attack and stroke. It does carry the risks of serious stomach and intestinal bleeding as well as skin reactions.
Talk to your doctor about whether NSAIDs are right for you. People who are older than 65 or who have existing heart, stomach, kidney, liver, or intestinal disease are at higher risk for problems. For other people, the benefits outweigh the risks.
Do not take NSAIDS if you have ever had an allergic reaction to any type of pain medicine.
If you are pregnant, trying to become pregnant, or breast-feeding, talk to your doctor before you use NSAIDs. It is especially important to avoid using NSAIDs during the last 3 months of pregnancy unless your doctor tells you to. They can cause problems with the baby or the delivery.
Talk to your doctor before taking NSAIDs if you have:
- Ulcers or a history of stomach or intestinal bleeding.
- Stomach pain, upset stomach, or heartburn that lasts or comes back.
- Anemia.
- Bleeding problems.
- A habit of drinking more than 3 alcoholic drinks a day. This increases your risk of stomach bleeding.
- High blood pressure.
- Kidney, liver, or heart disease.
- Any serious health condition.
Talk to your doctor before using NSAIDs if you take:
- Blood thinners (anticoagulants).
- Lithium.
- Diuretics (water pills).
- Medicine for arthritis or diabetes.
- ASA to protect your heart.
- Any other drugs.
Do not give ASA to anyone younger than 20 because of the risk of Reye's syndrome, a rare but serious disease.
| Author: | Jan Nissl, RN, BS | Last Updated: October 3, 2007 |
| Medical Review: | William M. Green, MD - Emergency Medicine H. Michael O'Connor, MD - Emergency Medicine | |
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