Capsaicin (Zostrix), available without a prescription, is a pain
reliever that comes in a cream that you apply directly to your skin (topical
analgesic). It has been found to relieve joint pain from
osteoarthritis in some people when rubbed into the
skin over affected joints.1 To be beneficial, the
cream must be applied 3 or 4 times a day, and the effects may not be seen for
several weeks.
The main ingredient in capsaicin is an extract from hot peppers. It
appears to have no serious side effects. However, some people may be allergic
to capsaicin. The first time you use this topical cream, apply it to just a
small area of skin to make sure there is no allergic reaction. Even people who
are not allergic may notice a burning sensation. Some people may not be able to
tolerate the discomfort associated with using capsaicin.